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Article

Biomechanics of T Cell Dysfunctions in Chronic Diseases.

Frontiers in immunology - 1 Jan 2021

Gunasinghe Sachith D, Peres Newton G, Goyette Jesse, Gaus Katharina

Abstract excerpt

Understanding the mechanisms behind T cell dysfunctions during chronic diseases is critical in developing effective immunotherapies. As demonstrated by several animal models and human studies, T cell dysfunctions are induced during chronic diseases, spanning from infections to cancer. Although factors governing the onset and the extent of the functional impairment of T cells can differ during infections and...

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Identifiers

PMID: 33717081
DOI: 10.3389/fimmu.2021.600829
PMCID: PMC7948521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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