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Article

Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation.

European journal of immunology - 1 Jan 2014

Klieger Yair, Almogi-Hazan Osnat, Ish-Shalom Eliran, Pato Aviad, Pauker Maor H, Barda-Saad Mira, Wang Lynn, Baniyash Michal

Abstract excerpt

TCR-mediated activation induces receptor microclusters that evolve to a defined immune synapse (IS). Many studies showed that actin polymerization and remodeling, which create a scaffold critical to IS formation and stabilization, are TCR mediated. However, the mechanisms controlling simultaneous TCR and actin dynamic rearrangement in the IS are yet not fully understood. Herein, we identify two novel TCR ζ-chain...

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PMID: 24185712
DOI: 10.1002/eji.201243099

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