Article
Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement.
The Journal of allergy and clinical immunology - 1 Oct 2023
Gajardo Tania, Bernard Mathilde, Lô Marie, Turck Elisa, Leveau Claire, El-Daher Marie-Thérèse, Deslys Alexandre, Panikulam Patricia, Menche Constantin, Kurowska Mathieu, Le Lay Gregoire, Barbier Lucie, Moshous Despina, Neven Bénédicte, Farin Henner F, Fischer Alain, Ménasché Gaël, de Saint Basile Geneviève, Vargas Pablo, Sepulveda Fernando E
Abstract excerpt
BACKGROUND: The actin cytoskeleton has a crucial role in the maintenance of the immune homeostasis by controlling various cellular processes, including cell migration. Mutations in TTC7A have been described as the cause of a primary immunodeficiency associated to different degrees of gut involvement and alterations in the actin cytoskeleton dynamics. OBJECTIVES: This study investigates the impact of TTC7A...
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