Article

Actin dynamics regulation by TTC7A/PI4KIIIα axis limits DNA damage and cell death during leukocyte migration

2021-10-14

Abstract excerpt

The actin cytoskeleton has a crucial role in the maintenance of the immune homeostasis by controlling various cell processes, including cell migration. Mutations in the TTC7A gene have been described as the cause of a primary immunodeficiency associated to different degrees of gut involvement and alterations in the actin cytoskeleton dynamics. Although several cellular functions have been associated with TTC7A, t...

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Literature Corpus work: be1eeb91-09b6-59b3-8d99-0dbf67ebe0f0
DOI: 10.1101/2021.10.14.464382

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