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Overexpression of the <i>Apoe</i> gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behavior

2024-08-09

Abstract excerpt

Apolipoprotein E (ApoE) is a protein that is important for lipid storage, transport, and metabolism. APOE gene variants are associated with Alzheimer’s disease (AD), as well as attentional function in healthy humans. Previous research has shown that Apoe transcription is increased following stimulation of the pathway between the locus coeruleus (LC) and frontal cortex (FC) in mice. This result suggests that Apo...

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Literature Corpus work
81acc80e-9807-58cb-afe9-105aacc5485c
DOI
10.1101/2024.08.08.607225
Open publication

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Overexpression of the <i>Apoe</i> gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behaviorDOI 10.1101/2024.08.08.607225
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