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Article

Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders.

Molecular psychiatry - 1 Nov 2024

Hwang Hye M, Yamashita Satoshi, Matsumoto Yu, Ito Mariko, Edwards Alex, Sasaki Junko, Dutta Dipankar J, Mohammad Shahid, Yamashita Chiho, Wetherill Leah, Schwantes-An Tae-Hwi, Abreu Marco, Mahnke Amanda H, Mattson Sarah N, Foroud Tatiana, Miranda Rajesh C, Chambers Christina, Torii Masaaki, Hashimoto-Torii Kazue

Abstract excerpt

A hallmark of fetal alcohol spectrum disorders (FASD) is neurobehavioral deficits that still do not have effective treatment. Here, we present that reduction of Apolipoprotein E (APOE) is critically involved in neurobehavioral deficits in FASD. We show that prenatal alcohol exposure (PAE) changes chromatin accessibility of Apoe locus, and causes reduction of APOE levels in both the brain and peripheral blood in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38734844
DOI: 10.1038/s41380-024-02586-6
PMCID: PMC11541007

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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