Article

Sex- and Age-Dependent Mitochondrial Dysfunction Links Familial Hypercholesterolemia to Cognitive Impairment

2026-01-19

Abstract excerpt

<title>Abstract</title> <p> <bold>Background.</bold> Familial hypercholesterolemia (FH) is a genetic disorder of cholesterol metabolism caused by loss-of-function variants in the low-density lipoprotein receptor (LDLR), resulting in persistently elevated LDL-cholesterol levels in plasma. Although hypercholesterolemia, especially the high levels of LDL, has been linked to an increased risk of dementia, the under...

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Literature Corpus work: ecae859b-342e-5fcc-bad4-a3c3602572e9
DOI: 10.21203/rs.3.rs-8561934/v1

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