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Article

APOE4 genotype or ovarian hormone loss influence open field exploration in an EFAD mouse model of Alzheimer's disease.

Hormones and behavior - 1 Apr 2022

Taxier Lisa R, Philippi Sarah M, York Jason M, LaDu Mary Jo, Frick Karyn M

Abstract excerpt

Anxiety is a prominent and debilitating symptom in Alzheimer's disease (AD) patients. Carriers of APOE4, the greatest genetic risk factor for late-onset AD, may experience increased anxiety relative to carriers of other APOE genotypes. However, whether APOE4 genotype interacts with other AD risk factors to promote anxiety-like behaviors is less clear. Here, we used open field exploration to assess anxiety-like...

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Identifiers

PMID: 35101701
DOI: 10.1016/j.yhbeh.2022.105124
PMCID: PMC8976745

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