Article
Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase.
Nucleic acids research - 6 Sept 2016
Ren Zhong
Abstract excerpt
DNA polymerases in family B are workhorses of DNA replication that carry out the bulk of the job at a high speed with high accuracy. A polymerase in this family relies on a built-in exonuclease for proofreading. It has not been observed at the atomic resolution how the polymerase advances one nucleotide space on the DNA template strand after a correct nucleotide is incorporated, that is, a process known as...
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