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Article

Alpha-like subunits of multisubunit RNA polymerases: insights into structure, function, and disease.

RNA biology - 1 Dec 2026

Onuoha Onyinyechi C, Belkevich Alana E, Palumbo Ryan J, Knutson Bruce A

Abstract excerpt

Multisubunit RNA polymerases share a deeply conserved architectural core, yet their regulatory complexity has expanded dramatically over evolution. At the heart of this architecture lies an ancient assembly module formed by the alpha and alpha-like subunits. Originally emerging as a homodimeric scaffold in bacteria, this module was duplicated and partitioned into asymmetric heterodimers in archaea and eukaryotes....

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Identifiers

PMID: 42417148
DOI: 10.1080/15476286.2026.2700806
PMCID: PMC13374769

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