Article

Cryo-EM structure of the human CST•Polα/Primase complex in a recruitment state

2021-12-18

Abstract excerpt

The CST•Polα/Primase complex is essential for telomere overhang maintenance and additionally functions to counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure of CST•Polα/Primase, captured prior to catalysis in a recruitment state, which provides insights into the architecture and stoichiometry of the fill-in machinery. Our model informs on human disease mutations that cause...

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Literature Corpus work: 0a1248f4-bff1-5a4f-9c83-5c00c66e6373
DOI: 10.1101/2021.12.17.473235

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