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Article

Crystal structure of the human primase.

The Journal of biological chemistry - 27 Feb 2015

Baranovskiy Andrey G, Zhang Yinbo, Suwa Yoshiaki, Babayeva Nigar D, Gu Jianyou, Pavlov Youri I, Tahirov Tahir H

Abstract excerpt

DNA replication in bacteria and eukaryotes requires the activity of DNA primase, a DNA-dependent RNA polymerase that lays short RNA primers for DNA polymerases. Eukaryotic and archaeal primases are heterodimers consisting of small catalytic and large accessory subunits, both of which are necessary for RNA primer synthesis. Understanding of RNA synthesis priming in eukaryotes is currently limited due to the lack...

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Identifiers

PMID: 25550159
DOI: 10.1074/jbc.M114.624742
PMCID: PMC4342476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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