Article

Characterization of adult hippocampal neurogenesis in the novel <i> App <sup>SAA</sup> </i> Knock-in Alzheimer’s disease mouse model

2025-09-19

Abstract excerpt

Adult hippocampal neurogenesis (AHN) declines with age and is thought to be severely exacerbated in neurodegenerative disorders like Alzheimer’s disease (AD). Despite numerous efforts to understand how AHN is altered in AD mouse models, results have been inconsistent, largely due to limitations of first-generation transgenic AD mouse models. The newly developed App Knock-in models address many of these limitation...

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Literature Corpus work: 81753ed8-9712-51e1-8e3b-29a031b844c4
DOI: 10.1101/2025.09.18.677216

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