Article

Loss of newborn neuron function accelerates neuroinflammation and amyloid accumulation via dentate gyrus circuit alteration in a mouse model of Alzheimer’s disease

2026-03-26

Abstract excerpt

<title>Abstract</title> Background Chronic neuroinflammation, characterized by persistent activation of microglia and astrocytes, is now recognized not merely as a bystander but as a fundamental driver of Alzheimer’s disease (AD) pathogenesis. Importantly, neuroinflammatory processes have been reported to be associated with disruptions in excitation–inhibition balance and network instability. Adult hippocam...

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Literature Corpus work: 83e80eaf-8a12-51b5-ae5d-9fa6f876dbe2
DOI: 10.21203/rs.3.rs-9168444/v1

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