Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease.

doi:10.1016/j.expneurol.2006.09.018

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Article

Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease.

Experimental neurology - 1 Mar 2007

Zhang Chen, McNeil Elizabeth, Dressler Lindsay, Siman Robert

Abstract excerpt

Neurogenesis in the adult hippocampus has been implicated in regulating long-term memory and mood, but its integrity in Alzheimer's disease (AD) is uncertain. Studies of neurogenesis in transgenic mouse models of familial AD are complicated by ectopic overexpression restricted to terminally diffe...

Topics

Alzheimer Disease
Amyloid
Amyloid beta-Protein Precursor
Animals
Dentate Gyrus
Disease Models, Animal
Doublecortin Domain Proteins
Female
Gliosis
Hippocampus
Male
Mice
Mice, Transgenic
Microtubule-Associated Proteins
Mutation
Neurons
Neuropeptides
Olfactory Bulb

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Identifiers

PMID: 17070803
DOI: 10.1016/j.expneurol.2006.09.018
PMCID: PMC1853320

Genes

APP
MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17070803-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

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Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.