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Article

Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease.

Experimental neurology - 1 Mar 2007

Zhang Chen, McNeil Elizabeth, Dressler Lindsay, Siman Robert

Abstract excerpt

Neurogenesis in the adult hippocampus has been implicated in regulating long-term memory and mood, but its integrity in Alzheimer's disease (AD) is uncertain. Studies of neurogenesis in transgenic mouse models of familial AD are complicated by ectopic overexpression restricted to terminally differentiated neurons, while AD cases have been studied only at the pre-senile or end-stage of disease. To investigate...

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Source

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Identifiers

PMID: 17070803
DOI: 10.1016/j.expneurol.2006.09.018
PMCID: PMC1853320

Genes

APP
MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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