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Article

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

20 Aug 2016

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the Western world and is characterized by a progressive loss of cognitive functions leading to dementia. One major histopathological hallmark of AD is the formation of amyloid-beta plaques, which is reproduced in numerous transgenic animal models overexpressing pathogenic forms of amyloid precursor protein (APP). In human AD and in...

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PMID: 27544234
DOI: 10.1007/s12035-016-0018-9

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