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Article

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice.

Journal of neuroscience research - 1 Aug 2010

Demars Michael, Hu Yuan-Shih, Gadadhar Archana, Lazarov Orly

Abstract excerpt

Formation of new neurons in the adult brain takes place in the subventricular zone and in the subgranule layer of the dentate gyrus throughout life. Neurogenesis is thought to play a role in hippocampus- and olfaction-dependent learning and memory. However, whether impairments in neurogenesis take place in learning and memory disorders, such as Alzheimer's disease, is yet to be established. Importantly, it...

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Identifiers

PMID: 20209626
DOI: 10.1002/jnr.22387
PMCID: PMC3696038

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Source receipt: pubmed, retrieved 7 Sept 2026.

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