Article
Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease.
Neurobiology of aging - 1 Mar 2011
Faure A, Verret L, Bozon B, El Tannir El Tayara N, Ly M, Kober F, Dhenain M, Rampon C, Delatour B
Abstract excerpt
Amyloid-β peptide species accumulating in the brain of patients with Alzheimer's disease are assumed to have a neurotoxic action and hence to be key actors in the physiopathology of this neurodegenerative disease. We have studied a new mouse mutant (APPxPS1-Ki) line developing both early-onset brain amyloid-β deposition and, in contrast to most of transgenic models, subsequent neuronal loss. In 6-month-old mice,...
Topics
- Age Factors
- Aging
- Alzheimer Disease
- Amyloid
- Amyloid beta-Protein Precursor
- Analysis of Variance
- Animals
- Animals, Genetically Modified
- Anxiety
- Brain
- Cognition Disorders