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Article

Wild-Type Neural Progenitors Divide and Differentiate Normally in an Amyloid-Rich Environment

30 Oct 2013

Abstract excerpt

Adult neurogenesis is modulated by a balance of extrinsic signals and intrinsic responses that maintain production of new granule cells in the hippocampus. Disorders that disrupt the proliferative niche can impair this process, and alterations in adult neurogenesis have been described in human autopsy tissue and transgenic mouse models of Alzheimer's disease. Because exogenous application of aggregated Aβ peptide...

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PMID: 24174666
DOI: 10.1523/jneurosci.1917-13.2013

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