Article

Single-cell transcriptome analysis of the immunosuppressive effect of differential expression of tumor PD-L1 on responding TCR-T cells

2020-07-24

Abstract excerpt

PD-L1 expression levels in tumors do not consistently predict cancer patients’ response to PD-(L)1 inhibitors. We therefore evaluated how tumor PD-L1 levels affect the anti-PD-(L)1 efficacy and T cell function. We used MART-1-specific TCR-T cells (TCR-T MART-1 ) stimulated with MART-1 27-35 peptide-loaded MEL-526 tumor cells with different proportions of them expressing PD-L1 to perform cellular assays and high-...

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Literature Corpus work: de1b0eee-9453-5850-8ed6-29ff7af66b51
DOI: 10.1101/2020.07.23.217059

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