Article

More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway

2022-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology. While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsic functions in immune and cancer cells. In line with these studies, here we show that engagement of PD-L1 via cellular ligands or agonistic antibodies, includi...

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Literature Corpus work: da82cc14-33f2-5cf2-b92c-6eec7e5d5315
DOI: 10.1101/2022.08.31.506095

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More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathwayDOI 10.1101/2022.08.31.506095Read

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