Article
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Cell metabolism - 8 Nov 2016
Brand Almut, Singer Katrin, Koehl Gudrun E, Kolitzus Marlene, Schoenhammer Gabriele, Thiel Annette, Matos Carina, Bruss Christina, Klobuch Sebastian, Peter Katrin, Kastenberger Michael, Bogdan Christian, Schleicher Ulrike, Mackensen Andreas, Ullrich Evelyn, Fichtner-Feigl Stefan, Kesselring Rebecca, Mack Matthias, Ritter Uwe, Schmid Maximilian, Blank Christian, Dettmer Katja, Oefner Peter J, Hoffmann Petra, Walenta Stefan, Geissler Edward K, Pouyssegur Jacques, Villunger Andreas, Steven André, Seliger Barbara, Schreml Stephan, Haferkamp Sebastian, Kohl Elisabeth, Karrer Sigrid, Berneburg Mark, Herr Wolfgang, Mueller-Klieser Wolfgang, Renner Kathrin, Kreutz Marina
Abstract excerpt
Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mice, tumors with reduced lactic acid production (Ldhalow) developed significantly slower than control tumors and showed increased infiltration with IFN-γ-producing T...
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