Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells.

Journal of molecular medicine (Berlin, Germany) - 1 Oct 2020

Andreucci Elena, Peppicelli Silvia, Ruzzolini Jessica, Bianchini Francesca, Biagioni Alessio, Papucci Laura, Magnelli Lucia, Mazzanti Benedetta, Stecca Barbara, Calorini Lido

Abstract excerpt

Acidosis characterizes the microenvironment of most solid tumors and is considered a new hallmark of cancer. It is mainly caused by both "aerobic" and "anaerobic" glycolysis of differently adapted cancer cells, with the final product lactic acid being responsible of the extracellular acidification. Many evidences underline the role of extracellular acidosis in tumor progression. Among the different findings, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acidosis
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Space

Share to Glycolysis

Share to Hydrogen-Ion Concentration

Share to Melanoma

Share to Neoplastic Stem Cells

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 32803272
DOI: 10.1007/s00109-020-01959-y
PMCID: PMC7525286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells.PMID 32803272Read ↗

Acid treatment of melanoma cells selects for invasive phenotypes.Semantic proximity Read ↗

Therapeutic Targeting of Cancer Stem Cells: Integrating and Exploiting the Acidic NicheSemantic proximity Read ↗

Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation.Semantic proximity Read ↗

Phenotypic changes of acid-adapted cancer cells push them toward aggressiveness in their evolution in the tumor microenvironment.Semantic proximity Read ↗

Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and in vivo metastasisSemantic proximity Read ↗

The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cellsSemantic proximity Read ↗

Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and <i>in vivo</i> metastasisSemantic proximity Read ↗

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic moleculesSemantic proximity Read ↗

Cutaneous pH landscape as a facilitator of melanoma initiation and progression.Semantic proximity Read ↗

Fatal Alliance of Hypoxia-/HIF-1α-Driven Microenvironmental Traits Promoting Cancer Progression.Semantic proximity Read ↗

Metabolism and its sequelae in cancer evolution and therapy.Semantic proximity Read ↗

The hypoxic microenvironment: A determinant of cancer stem cell evolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.