Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced tumor response to adoptive T cell therapy with PHD2/3-deficient CD8 T cells

6 Sept 2024

Abstract excerpt

While adoptive cell therapy has shown success in hematological malignancies, its potential against solid tumors is hindered by an immunosuppressive tumor microenvironment (TME). In recent years, members of the hypoxia-inducible factor (HIF) family have gained recognition as important regulators of T-cell metabolism and function. The role of HIF signalling in activated CD8 T cell function in the context of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39242595
DOI: 10.1038/s41467-024-51782-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced tumor response to adoptive T cell therapy with PHD2/3-deficient CD8 T cellsPMID 39242595Read ↗

Modified Hypoxia Inducible Factor expression in CD8+ T cells increases anti-tumor efficacySemantic proximity Read ↗

Metabolic reprogramming through PIM3 inhibition reverses hypoxia-induced CAR-T cell dysfunction in solid tumors.Semantic proximity Read ↗

Tarloxotinib targets tumor hypoxia to improve therapeutic efficacy of immune checkpoint inhibition in a TLR9 dependent mannerSemantic proximity Read ↗

TCR-T Modulation and Epigenetic Reprogramming for a Personalised Therapeutic Approach in ImmunotherapySemantic proximity Read ↗

Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncologySemantic proximity Read ↗

The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cellsSemantic proximity Read ↗

The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cellsSemantic proximity Read ↗

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies.Semantic proximity Read ↗

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and functionSemantic proximity Read ↗

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumorsSemantic proximity Read ↗

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell functionSemantic proximity Read ↗

ATF4 programs proline-dependent immune evasion in β-Catenin-driven hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.