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Article

Sympathetic neurons exacerbate atherosclerosis by modulating macrophage function via the NPY/Y1R axis.

Atherosclerosis - 1 Aug 2026

Fan Yubao, Li Dairui, Chen Qiumin, Yuan Haiyun, Hu Luoming, Chen Weimin, Li Weiqiang, Liu Jia, Chen Jimei

Abstract excerpt

BACKGROUND AND AIMS: Neuroimmune crosstalk is increasingly recognized in atherosclerosis, yet the contribution of the sympathetic neuron-macrophage axis remains unclear. We investigated whether and how sympathetic innervation promotes atherosclerosis through modulation of macrophage phenotype and function. METHODS: ApoE-/- mice with or without sympathetic denervation were fed a high-fat diet to examine the role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42378921
DOI: 10.1016/j.atherosclerosis.2026.120834

Genes

NPY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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