Article

GATA2 Induces a Stem Cell-Like Transcriptional Program in Macrophages that Promotes Atherogenesis

2025-07-22

Abstract excerpt

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden necrotic macrophages within blood vessels walls. GATA2 is a normally hematopoietic transcription factor which in the bone marrow helps maintain the proliferative, non-differentiated phenotype of hematopoietic progenitors. Unexpectedly, GATA2 is upregulated in macrophages within atherosclerotic plaque, where it plays...

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Literature Corpus work: a7f8dcf6-bfd8-57c6-b9d6-8c21ea8dbd5c
DOI: 10.1101/2025.07.18.665581

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