Article
Olfr2-positive macrophages originate from monocytes proliferate in situ and present a pro-inflammatory foamy-like phenotype.
Cardiovascular research - 5 Nov 2024
Armstrong Suthahar Sujit Silas, Nettersheim Felix Sebastian, Alimadadi Ahmad, Wang Erpei, Billitti Monica, Resto-Trujillo Natalya, Roy Payel, Hedrick Catherine C, Ley Klaus, Orecchioni Marco
Abstract excerpt
AIMS: Olfactory receptor 2 (Olfr2) has been identified in a minimum of 30% of vascular macrophages, and its depletion was shown to reduce atherosclerosis progression. Mononuclear phagocytes, including monocytes and macrophages within the vessel wall, are major players in atherosclerosis. Single-cell RNA sequencing studies revealed that atherosclerotic artery walls encompass several monocytes and vascular...
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