Article

miR487a-3p and miR6855-3p Facilitate Macrophage Pro-inflammatory Polarization and Lipid Accumulation in Atherosclerosis

2026-05-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> The integrated regulation of microRNAs (miRNAs) on macrophage plasticity plays a key role in atherosclerosis (AS). We tested the hypothesis that miR487a-3p and miR6855-3p accelerate AS by intensifying macrophage inflammatory response and metabolic dysregulation. <h4>METHODS</h4> MiRNA sequencing (miR-seq) and mRNA sequencing (mRNA-seq) were conducted in peripheral monocytes...

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Literature Corpus work: 5eee5746-c0f8-5f44-9753-07b6339dabd4
DOI: 10.64898/2026.05.21.26353835

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