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Article

NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis.

Circulation research - 3 Feb 2012

Hanna Richard N, Shaked Iftach, Hubbeling Harper G, Punt Jennifer A, Wu Runpei, Herrley Erica, Zaugg Claudia, Pei Hong, Geissmann Frederic, Ley Klaus, Hedrick Catherine C

Abstract excerpt

RATIONALE: NR4A1 (Nur77) is a nuclear receptor that is expressed in macrophages and within atherosclerotic lesions, yet its function in atherosclerosis is unknown. OBJECTIVE: Nur77 regulates the development of monocytes, particularly patrolling Ly6C(-) monocytes that may be involved in resolution of inflammation. We sought to determine how absence of nuclear receptor subfamily 4, group A, member 1 (NR4A1) in...

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Identifiers

PMID: 22194622
DOI: 10.1161/CIRCRESAHA.111.253377
PMCID: PMC3309661

Genes

NR4A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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