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Article

Single-Cell Analysis Reveals a Critical Role for Macrophage Epsins in Regulating the Origin of Foam Cells in Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2025

Arulsamy Kulandaisamy, Cui Kui, Zhu Bo, Wang Beibei, Eisa-Beygi Shahram, Voronova Anna, Gao Xinlei, Gupta Krishan, Zhang Lili, Chen Kaifu, Chen Hong

Abstract excerpt

BACKGROUND: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden foam cells and plaques within the arterial wall. Dysfunctional vascular smooth muscle cells (VSMCs), fibroblasts, endothelial cells, and macrophages contribute to disease progression. Here, we report that macrophage-specific expression of epsins, highly conserved endocytic adaptor proteins involved in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40931837
DOI: 10.1161/ATVBAHA.125.323288
PMCID: PMC12669475

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