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Article

Fortilin deficiency induces anti-atherosclerotic phenotypes in macrophages and protects hypercholesterolemic mice against atherosclerosis.

Communications biology - 11 Jul 2025

Wanachottrakul Nattaporn, Pinkaew Decha, Mukherjee Sandipan, Chunhacha Preedakorn, Nakashima Mari, Brockman Asa A, Pal Uttariya, Halim Hasseri B, Wei Yuhong, Tanaka Lena, Huynh Hanna, Ramana Kota, Chen Shiyou, Ihrie Rebecca A, Fujise Ken

Abstract excerpt

In the atherosclerotic intima, macrophages (MΦ) perpetuate chronic inflammation and cholesterol accumulation. Fortilin, a 172-amino-acid multifunctional protein, is abundant in the atherosclerotic intima and promotes atherogenesis, but its mechanism has remained unclear. Herein, we report that fortilin in MФ (fortilinMΦ) facilitates atherosclerosis by (a) enhancing MΦ survival, proliferation, and lipid uptake,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40640354
DOI: 10.1038/s42003-025-08425-w
PMCID: PMC12246171

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