Article

Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 catenin

2025-03-11

Abstract excerpt

The mechanosensing properties of endothelial cell-cell junctions are essential for vascular beds to respond to the mechanical forces exerted by blood flow. In states of disturbed flow, endothelial cells (ECs) become activated and transition to a pro-inflammatory, atheroprone phenotype. Here, we investigated the role of transmembrane glycoprotein neuropilin 2 (NRP2) in maintaining adherens junction integrity using...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b166cc55-01a4-5b0d-bcfe-3fa1d53c406c
DOI: 10.1101/2025.03.09.642194

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 cateninDOI 10.1101/2025.03.09.642194Read

NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 IntegrinSemantic proximity Read

Macrophage-expressed Neuropilin 2 promotes plaque formation in ApoE knockout mice and is essential for pro-inflammatory macrophage polarisation and gene expressionSemantic proximity Read

Neuropilins: structure, function and role in diseaseSemantic proximity Read

Neuropilin Functions as an Essential Cell Surface Receptor.Semantic proximity Read

Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.Semantic proximity Read

Latrophilin-2 mediates flow activation of Notch to control vascular endothelial phenotype and atherosclerosisSemantic proximity Read

Neuropilin signalling in angiogenesisSemantic proximity Read

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.Semantic proximity Read

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis.Semantic proximity Read

Endothelial Cell–Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact VasculatureSemantic proximity Read

Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammationSemantic proximity Read

Neuropilins in physiological and pathological angiogenesisSemantic proximity Read