Article

Cerebellar Granule Cells Develop Non-neuronal 3D Genome Architecture over the Lifespan

2023-02-25

Abstract excerpt

The cerebellum contains most of the neurons in the human brain, and exhibits unique modes of development, malformation, and aging. For example, granule cells—the most abundant neuron type—develop unusually late and exhibit unique nuclear morphology. Here, by developing our high-resolution single-cell 3D genome assay Dip-C into population-scale (Pop-C) and virus-enriched (vDip-C) modes, we were able to resolve the...

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Literature Corpus work: f1b47ec3-56e0-5b6d-8c16-5cf634fb4ce3
DOI: 10.1101/2023.02.25.530020

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