Article
Whole-genome 3D architectural screen reveals modulators of brain DNA structure
2026-04-17
Abstract excerpt
Three-dimensional (3D) genome architecture is the foundation of gene regulation, and plays a critical role in normal physiology and disease. However, our understanding of its biochemical determinants has long been limited by technology: imaging-based screens only profile a small number of loci, while sequencing-based studies rarely exceed 100 samples or conditions. Here we present “in-plate chromosome conformation...
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Identifiers and source
- Literature Corpus work
- 3166d1f0-f6f6-5392-b319-1e4584ca4304
- DOI
- 10.64898/2026.04.15.718501