Article

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

2018-12-27

Abstract excerpt

<h4>SUMMARY</h4> Epigenetic modifiers have emerged as important regulators of tumor progression. We identified histone methyltransferase KMT2D as a potent tumor-suppressor through an in vivo epigenome-focused pooled RNAi screen in melanoma. KMT2D harbors frequent somatic point mutations in multiple tumor types. How these events contribute to tumorigenesis and whether they impart therapeutic vulnerability are poo...

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Literature Corpus work: 80bd4f58-2d4a-5d34-8311-42ccea8edeec
DOI: 10.1101/507327

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