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The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

2020-09-07

Abstract excerpt

Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achieves a durable remission. SIRT5 is a member of the sirtuin family of protein deacylases that regulate metabolism and other biological processes. Germline Sirt5 deficien...

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Identifiers and source

Literature Corpus work
23bb3f83-2be6-503a-b3a1-ebfc5b4fdd9b
DOI
10.1101/2020.09.07.286526
Open publication

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The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamicsDOI 10.1101/2020.09.07.286526
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