Article
Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities.
Genome medicine - 22 Nov 2024
Takemon Yuka, Pleasance Erin D, Gagliardi Alessia, Hughes Christopher S, Csizmok Veronika, Wee Kathleen, Trinh Diane L, Huff Ryan D, Mungall Andrew J, Moore Richard A, Chuah Eric, Mungall Karen L, Lewis Eleanor, Nelson Jessica, Lim Howard J, Renouf Daniel J, Jones Steven Jm, Laskin Janessa, Marra Marco A
Abstract excerpt
BACKGROUND: Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required. METHODS: Here, we computationally map genetic networks of KMT2D, a tumour suppressor gene frequently mutated in several cancer types. Using KMT2D loss-of-function (KMT2DLOF) mutations as a model, we illustrate...
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