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Article

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma.

Journal of experimental & clinical cancer research : CR - 24 Sept 2022

Zarei Mehrdad, Hajihassani Omid, Hue Jonathan J, Graor Hallie J, Loftus Alexander W, Rathore Moeez, Vaziri-Gohar Ali, Asara John M, Winter Jordan M, Rothermel Luke D

Abstract excerpt

BACKGROUND: Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic dependency in cancer. The enzyme protects cancer cells under metabolic stress, including nutrient limited conditions in the tumor microenvironment. Specifically, IDH1 generates NADPH to maintain...

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Source

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Identifiers

PMID: 36153582
DOI: 10.1186/s13046-022-02489-w
PMCID: PMC9509573

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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