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Article

The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics

4 May 2021

Abstract excerpt

Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achieve a durable remission. Sirtuin 5 (SIRT5) is a member of the sirtuin family of protein deacylases that regulates metabolism and other biological processes. Germline...

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PMID: 33945506
DOI: 10.1172/jci138926

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