Article
A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAFV600E inhibition in melanoma.
Neoplasia (New York, N.Y.) - 1 Oct 2025
Zhou Jiang, Chai Xinxin, Zhu Yi, Huang Zhi, Lin Tingting, Hu Zhen, Chen Guangdi, Luo Chi, Cui Rutao, Sheng Jinghao
Abstract excerpt
The BRAFV600E pathway and epigenetic machinery are central to melanoma pathogenesis. However, how these processes intersect and their potential for synthetic lethality remains unclear. Here, we identified a BRAFV600E-driven epigenetic mechanism in melanoma that involves a H3K27 methylation-to-acetylation switch, facilitating metabolic adaptation to targeted therapies. Inhibition of BRAFV600E downregulates the...
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