Article

KMT2D Loss Promotes Head and Neck Squamous Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment

2021-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with 5-year survival of ∼50%. Genomic profiling studies have identified important somatic mutations in this disease which presents an opportunity for precision medicine. We demonstrate that KMT2D, a histone methyltransferase harbors somatic mutations in ∼17% of HNSCC and is associated with 2-year recurrence...

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Literature Corpus work: 7898f7db-c991-5638-9546-edae84b8bf81
DOI: 10.1101/2021.09.21.461314

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