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Article

Metabolic rewiring in melanoma.

Oncogene - 12 Jan 2017

Ratnikov B I, Scott D A, Osterman A L, Smith J W, Ronai Z A

Abstract excerpt

Oncogene-driven metabolic rewiring is an adaptation to low nutrient and oxygen conditions in the tumor microenvironment that enables cancer cells of diverse origin to hyperproliferate. Aerobic glycolysis and enhanced reliance on glutamine utilization are prime examples of such rewiring. However, tissue of origin as well as specific genetic and epigenetic changes determines gene expression profiles underlying...

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Share to Tumor Microenvironment
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to MAP Kinase Signaling System

Share to Melanoma

Share to Proto-Oncogene Proteins B-raf

Share to Skin Neoplasms

Source

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Identifiers

PMID: 27270434
DOI: 10.1038/onc.2016.198
PMCID: PMC5140782

Genes

BRAF
MITF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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