In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

doi:10.1158/2159-8290.CD-15-1200

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Article

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Cancer discovery - 1 Jun 2016

Bossi Daniela, Cicalese Angelo, Dellino Gaetano I, Luzi Lucilla, Riva Laura, D'Alesio Carolina, Diaferia Giuseppe R, Carugo Alessandro, Cavallaro Elena, Piccioni Rossana, Barberis Massimo, Mazzarol Giovanni, Testori Alessandro, Punzi Simona, Pallavicini Isabella, Tosti Giulio, Giacó Luciano, Melloni Giorgio, Heffernan Timothy P, Natoli Gioacchino, Draetta Giulio F, Minucci Saverio, Pelicci PierGiuseppe, Lanfrancone Luisa

Abstract excerpt

UNLABELLED: The identification of genes maintaining cancer growth is critical to our understanding of tumorigenesis. We report the first in vivo genetic screen of patient-derived tumors, using metastatic melanomas and targeting 236 chromatin genes by expression of specific shRNA libraries. Our screens revealed unprecedented numerosity of genes indispensable for tumor growth (∼50% of tested genes) and unexpected...

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PMID: 27179036
DOI: 10.1158/2159-8290.CD-15-1200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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