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Mapping <i>in silico</i> genetic networks of the <i>KMT2D</i> tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

2024-01-20

Abstract excerpt

Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required. Here, we computationally map genetic networks of KMT2D , a tumour suppressor gene frequently mutated in several cancer types. Using KMT2D loss-of-function ( KMT2D LOF ) mutations as a model, we illustrate the utility of...

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Literature Corpus work
7000fa4d-1f40-556b-a28f-502b77a9064f
DOI
10.1101/2024.01.17.575929
Open publication

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Mapping <i>in silico</i> genetic networks of the <i>KMT2D</i> tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilitiesDOI 10.1101/2024.01.17.575929
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