Article

CRTC-1 balances histone trimethylation and acetylation to promote longevity

2022-09-02

Abstract excerpt

<h4>SUMMARY</h4> Loss of function during ageing is accompanied by transcriptional drift, altering gene expression and contributing to a variety of age-related diseases. CREB-regulated transcriptional coactivators (CRTCs) have emerged as key regulators of gene expression that might be targeted to promote longevity. Here, we define the role of the Caenorhabditis elegans CRTC-1 in the epigenetic regulation of longe...

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Literature Corpus work: 805566b1-25ad-5b4c-9b08-587cd1beb260
DOI: 10.1101/2022.08.31.506037

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