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A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

14 May 2021

Abstract excerpt

Age-related changes to histone levels are seen in many species. However, it is unclear whether changes to histone expression could be exploited to ameliorate the effects of ageing in multicellular organisms. Here we show that inhibition of mTORC1 by the lifespan-extending drug rapamycin increases expression of histones H3 and H4 post-transcriptionally through eIF3-mediated translation. Elevated expression of...

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Share to Autophagy in Disease and Therapy
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PMID: 33988501
DOI: 10.7554/elife.62233

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