Article

Continuous negative autoregulation fine-tunes dosage-sensitive transcription factor expression to maintain post-mitotic neuron identity

2026-05-15

Abstract excerpt

<h4>ABSTRACT</h4> How post-mitotic neurons maintain precise transcription factor (TF) levels throughout life remains a fundamental open question. Here, we challenge the prevailing model of positive autoregulation by demonstrating that UNC-3 (Collier/EBF1-4), a dosage-sensitive TF continuously required for cholinergic motor neuron identity in C. elegans , negatively regulates its own expression. Using genetics, b...

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Literature Corpus work: 0f6b660f-6365-5e21-b974-69732d3c1355
DOI: 10.64898/2026.05.14.725191

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