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Article

A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory.

Nature communications - 9 Jan 2026

Zeng Chenming, Furlan Giulia, Almeida Miguel Vasconcelos, Rueda-Silva Juan C, Price Jonathan, Santos-Rosa Helena, Xu Jingxiu, Kuang Yan, Socias Enric Cata, Mars Jonas, Rebelo-Guiomar Pedro, Huang Meng, Guang Shouhong, Butter Falk, Miska Eric A

Abstract excerpt

Transgenerational epigenetic inheritance (TEI) allows epigenetic information to pass across generations through mechanisms such as small RNAs and histone modifications. Histone methylation is often deposited by SET domain-containing methyltransferases. Some SET proteins lack catalytic activity but still regulate chromatin and gene expression. Here, we characterize SET-24, a catalytically inactive SET domain...

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PMID: 41513691
DOI: 10.1038/s41467-025-68200-7
PMCID: PMC12886896

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SET

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