Article

Adult-specific trimethylation of histone H3 lysine 4 is prone to dynamic changes with aging in <i>C. elegans</i> somatic cells

2017-12-18

Abstract excerpt

Tri-methylation on histone H3 lysine 4 (H3K4me3) is associated with active gene expression but its regulatory role in transcriptional activation is unclear. Here we used Caenorhabditis elegans to investigate the connection between H3K4me3 and gene expression regulation during aging. We uncovered around 30% of H3K4me3 enriched regions to show significant and reproducible changes with age. We further showed that th...

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Literature Corpus work: 5d3989bd-8034-58ed-8a33-31efc8925437
DOI: 10.1101/236257

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