Article

A conserved role of CBP/p300 in mitochondrial stress response and longevity

2020-10-14

Abstract excerpt

<title>Abstract</title> <p>Organisms respond to mitochondrial stress by activating multiple defense pathways including the mitochondrial unfolded protein response (UPRmt). However, how different layers of UPRmt regulators are orchestrated to transcriptionally activate the stress responses remains largely unknown. Here we identified CBP-1, the worm ortholog of the mammalian acetyltransferases CBP/p300, as an essen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c5c3357-4aa3-5f49-876f-bc89954510c7
DOI: 10.21203/rs.3.rs-86465/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A conserved role of CBP/p300 in mitochondrial stress response and longevityDOI 10.21203/rs.3.rs-86465/v1Read

Emerging roles of p300/CBP in autophagy and autophagy-related human disordersSemantic proximity Read

CRTC-1 balances histone trimethylation and acetylation to promote longevitySemantic proximity Read

HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans.Semantic proximity Read

Six drivers of aging identified among genes differentially expressed with ageSemantic proximity Read

Is histone acetylation the most important physiological function for CBP and p300?Semantic proximity Read

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.Semantic proximity Read

Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s DiseaseSemantic proximity Read

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Semantic proximity Read

SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.Semantic proximity Read

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional MechanismsSemantic proximity Read

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levelsSemantic proximity Read

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in <i>C. elegans</i> via degradation of Intrinsically Disordered ProteinsSemantic proximity Read